http://www.inquiriesjournal.com/keyword/stem-cells Inquiries Journal provides undergraduate and graduate students around the world a platform for the wide dissemination of academic work over a range of core disciplines. en-us Sat, 30 May 2026 00:43:41 -0400 Sat, 30 May 2026 00:43:41 -0400 http://www.inquiriesjournal.com/articles/199/using-stem-cell-and-gene-therapy-technologies-to-treat-parkinsons-disease By Heena Mulchandani - The sudden onset of Parkinsonism in drug addicts consuming the heroin- analogue MPTP in the 1980’s, led to its discovery as a potential cause of sporadic PD; indeed several chemical agents such as Rotenone have also received considerable attention (2). Although its etiology is still incompletely understood, the role of genetics in the pathogenesis of PD has been hotly debated for decades. The recent discovery of at least five genes (such as a-synuclein and parkin (Park-2))(3) together with animal lesion models (6-OHDA, MPTP, Rotenone) and human post mortem tissue analysis has polarized belief... Wed, 10 Mar 2010 08:45 EST http://www.inquiriesjournal.com/articles/199/using-stem-cell-and-gene-therapy-technologies-to-treat-parkinsons-disease http://www.inquiriesjournal.com/articles/193/recent-advances-in-neural-stem-cell-research-how-stem-cells-in-the-brain-are-altered-by-a-changing-environment By Heena Mulchandani - Our current knowledge indicates that the production of new cells in the brain follows a multi-step process during which newborn cells are submitted to various regulatory factors that influence cell proliferation, maturation, fate determination and survival. Progenitor cells isolated from the forebrain can differentiate into neurons in vitro, as was demonstrated by Reynolds and Weiss in 1992 (Gage, 2000). Since then NSCs have been isolated from various areas of the adult brain, including non-neurogenic areas such as the spinal cord. Today we know that there are two discrete regions - the Subgranular... Thu, 04 Mar 2010 09:00 EST http://www.inquiriesjournal.com/articles/193/recent-advances-in-neural-stem-cell-research-how-stem-cells-in-the-brain-are-altered-by-a-changing-environment