http://www.inquiriesjournal.com/keyword/sleep_wake-cycle Inquiries Journal provides undergraduate and graduate students around the world a platform for the wide dissemination of academic work over a range of core disciplines. en-us Sun, 12 Apr 2026 12:11:28 -0400 Sun, 12 Apr 2026 12:11:28 -0400 http://www.inquiriesjournal.com/articles/743/melatonin-and-sleep-disorders-the-neurobiology-of-sleep-circadian-rhythm-sleep-disorders-and-various-treatment-methods By Martha A. Dimech - Melatonin is a lipophilic, indolic-structured compound found ubiquitously in nature. This ubiquity suggests that such an evolutionarily conserved molecule participates in phylogenetically primordial signalling mechanisms of key importance to life. Melatonin’s versatility is shown in its various physiological functions including immunomodulation, antioxidation and its role as an oncostatic agent. Synthesis mainly occurs in the pineal gland; extrapineal sites include the retina, the brain and the gut. Endogenous secretion occurs at night with a marked circadian rhythm regulated by the body... Wed, 10 Jul 2013 05:37 EDT http://www.inquiriesjournal.com/articles/743/melatonin-and-sleep-disorders-the-neurobiology-of-sleep-circadian-rhythm-sleep-disorders-and-various-treatment-methods