http://www.inquiriesjournal.com/keyword/neurodegenerative-disease Inquiries Journal provides undergraduate and graduate students around the world a platform for the wide dissemination of academic work over a range of core disciplines. en-us Wed, 03 Jun 2026 17:38:23 -0400 Wed, 03 Jun 2026 17:38:23 -0400 http://www.inquiriesjournal.com/articles/1507/genetics-pathology-and-potential-future-advances-in-the-study-of-huntingtons-disease By Matthew D. Rose - Huntington’s disease is a progressive neurodegenerative disorder that affects around five people in every 100,000. It is caused by an increase in a polyglutamine region of the Huntingtin protein, resulting in a toxic gain of function mutation. However, the exact mechanism of pathogenesis, or even the exact role of the normal Huntingtin protein are not comprehensively understood. It is known that Huntingtin is ubiquitously expressed and has interactions with many different cellular components. Mutant Huntingtin has been extensively studied and its effects on cells noted but questions regarding... Tue, 13 Dec 2016 02:05 EST http://www.inquiriesjournal.com/articles/1507/genetics-pathology-and-potential-future-advances-in-the-study-of-huntingtons-disease http://www.inquiriesjournal.com/articles/193/recent-advances-in-neural-stem-cell-research-how-stem-cells-in-the-brain-are-altered-by-a-changing-environment By Heena Mulchandani - Our current knowledge indicates that the production of new cells in the brain follows a multi-step process during which newborn cells are submitted to various regulatory factors that influence cell proliferation, maturation, fate determination and survival. Progenitor cells isolated from the forebrain can differentiate into neurons in vitro, as was demonstrated by Reynolds and Weiss in 1992 (Gage, 2000). Since then NSCs have been isolated from various areas of the adult brain, including non-neurogenic areas such as the spinal cord. Today we know that there are two discrete regions - the Subgranular... Thu, 04 Mar 2010 09:00 EST http://www.inquiriesjournal.com/articles/193/recent-advances-in-neural-stem-cell-research-how-stem-cells-in-the-brain-are-altered-by-a-changing-environment