http://www.inquiriesjournal.com/keyword/molecular-genetics Inquiries Journal provides undergraduate and graduate students around the world a platform for the wide dissemination of academic work over a range of core disciplines. en-us Sat, 06 Jun 2026 06:58:16 -0400 Sat, 06 Jun 2026 06:58:16 -0400 http://www.inquiriesjournal.com/articles/1507/genetics-pathology-and-potential-future-advances-in-the-study-of-huntingtons-disease By Matthew D. Rose - Huntington’s disease is a progressive neurodegenerative disorder that affects around five people in every 100,000. It is caused by an increase in a polyglutamine region of the Huntingtin protein, resulting in a toxic gain of function mutation. However, the exact mechanism of pathogenesis, or even the exact role of the normal Huntingtin protein are not comprehensively understood. It is known that Huntingtin is ubiquitously expressed and has interactions with many different cellular components. Mutant Huntingtin has been extensively studied and its effects on cells noted but questions regarding... Tue, 13 Dec 2016 02:05 EST http://www.inquiriesjournal.com/articles/1507/genetics-pathology-and-potential-future-advances-in-the-study-of-huntingtons-disease http://www.inquiriesjournal.com/articles/894/molecular-detection-of-complex-vertebral-malformation-in-holstein-calves By Sahil Aggarwal - Complex vertebral malformation (CVM) in Holstein calves is a recessive syndrome that is the result of a transversion mutation within the SLC35A3 gene (Thomsen et al. 2006). Though a simple point mutation, this transversion results in high embryonic mortality and severe phenotypic abnormalities in surviving calves, such as growth retardation, vertebral malformation, and arthrogryposis (Agerholm et al. 2001). It is important to identify CVM carriers within the dairy market in order to effectively remove them from breeding centers and reduce the number of offspring with CVM. (Wang et al. 2012). CVM... Sun, 04 May 2014 01:04 EDT http://www.inquiriesjournal.com/articles/894/molecular-detection-of-complex-vertebral-malformation-in-holstein-calves