http://www.inquiriesjournal.com/keyword/hormone-replacement Inquiries Journal provides undergraduate and graduate students around the world a platform for the wide dissemination of academic work over a range of core disciplines. en-us Tue, 07 Apr 2026 11:35:47 -0400 Tue, 07 Apr 2026 11:35:47 -0400 http://www.inquiriesjournal.com/articles/800/the-contribution-of-hpg-axis-hormones-and-hormone-replacement-timing-on-cognition-and-associated-signaling By Jesal Shah - Many women experiencing menopause show cognitive function deficits and have an increased risk of developing Alzheimer's Disease (AD). While estrogen (E2) has been shown to improve cognition and improve molecular signaling associated with learning and memory, these effects are lost if estrogen replacement is not started within a critical time period, close to menopause onset. During menopause the ovaries no longer produce estrogen. Thus, the negative feedback of estrogen onto gonadotropin production is lost, and gonadotropins such as Luteinizing Hormone (LH) increase substantially. The downregulation... Thu, 21 Nov 2013 11:21 EST http://www.inquiriesjournal.com/articles/800/the-contribution-of-hpg-axis-hormones-and-hormone-replacement-timing-on-cognition-and-associated-signaling